PhD Studentship: Identifying genes for familial Parkinson’s disease • Deutsches Zentrum für Neurodegenerative Erkrankunge e. V. (DZNE) • Tübingen, Germany.
|Time Span||01 Feb 2021 for 3 years|
|Application Deadline||31 Jan 2021|
|Type of Position||
|Field of Research||
|Description||The German Center for Neurodegenerative Diseases (DZNE) is a world-leading internationally oriented research center, committed to discovering new approaches to prevent and treat neurodegenerative diseases. To this end, researchers at ten DZNE sites across Germany pursue a translational and interdisciplinary strategy comprising five interconnected areas: fundamental research, clinical research, health care research, population health science, and systems medicine.
The DZNE site Tübingen is offering a
PhD Studentship: Identifying genes for familial Parkinson’s disease – Code 3054/2020/12
This PhD will form part of the Aligning Science Across Parkinson’s (ASAP) Initiative – Global Parkinson’s Genetics Program (GP2). The Global Parkinson’s Genetics Program (GP2) (https://parkinsonsroadmap.org/gp2/) is an ambitious five-year program to further understand the genetic architecture of Parkinson’s disease (PD). There is still much to learn about genetic risk factors and the path to further understanding requires working collaboratively and openly sharing data, processes, and results.
In our preliminary work we have identified a number of genes that cause familial forms of Parkinson’s disease (PD). These findings have been fundamental for our understanding of the disease process and have been central in the current efforts to develop therapeutic approaches for the disease. However, the genetic causes for the majority of families still remain poorly understood.
As part of the ASAP-GP2 initiative we launched a global initiative to collect families with PD worldwide with the goal to identify novel genes that can cause familial PD.
The PhD project will combine the analysis of Whole Genome Sequencing (WGS) data including the novo genome assemblies, but would also include interpreting family pedigrees and clinical reports of patients for linkage and haplotype analysis.
This will be a collaborative project, based within the ASAP-GP2 Monogenic Disease Core at the DZNE Tübingen in Germany and supervised by Peter Heutink and Thomas Gasser. A training period at other sites within the ASAP-GP2 consortium would be encouraged (depending on traveling restrictions). As part of ASAP-GP2, the PhD will join a global initiative integrating clinical and genetic data from families with PD worldwide. There will be opportunities for collaboration with leaders in PD genetics across the GP2 network.
Three-year funded PhD studentship starting in January/February 2021. Payment and social benefits are consistent with those at other research institutes.
The PhD studentship is available to international students (f/m/d), including applicants from regions of the world that are underrepresented in research. However, the successful applicant would be expected to study in Tübingen, Germany.
– Master degree in a relevant discipline
Desirable criteria (training will be provided as part of the PhD program)
– Experience in bioinformatics and statistics
You will obtain special skills and knowledge for your scientific qualification during your activities at DZNE. The DZNE is an equal opportunity employer. It is committed to employing disabled individuals and especially encourages them to apply.
Please submit applications in the following format:
– A CV or biographical sketch (2 pages maximum) with the file name convention: Last name, first name(s), CV.
For more information, (not application!) about the project please email firstname.lastname@example.org
Please submit your application via: https://jobs.dzne.de/en/jobs/50672/form
The application deadline is January 31st, 2021.
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