Postdoc position in cell biology – Protein centric studies of immune cell regulation and immune modulating cancer drugs (Scholarship), Karolinska Institute, Sweden
Deadline:05 Nov 2020
Do you want to contribute to top quality medical research?
In spite of major advances in oncology in recent decades, many cancers cannot be controlled with current therapies. Improved understanding of cancer processes and general requirement of cancer drug efficacy is therefore urgently needed. Proteins are key players in most cellular events but a detailed understanding of protein action in many cellular processes and during drug therapy is often lacking.
Pär Nordlund’s research group is developing novel approaches to study proteins in intact cells based on biophysical readouts. The group has for example developed the transformative CETSA (Cellular Thermal Shift Assay) method (Martinez Molina, Science, 2013, 41:84; Dai, Cell, 2018, 173:1481). The mass-spectrometry implementation of the method (MS-CETSA) allows for interactive studies of proteins in cellular proteomes while cells transfer through a process or when a drug acts in the cell. This gives unique insights into the mechanics of the cell, e.g. if and when a protein are making novel interactions in regulatory or executive cellular processes, and which specific interactions are changed. The group is now exploring this novel approach, in parallel with other omics and cell biology approaches, to understand cancer related process as well as the action of clinical and novel cancer drugs.
We are looking for a Postdoc to join Pär Nordlund´s research group. The focus of the project is studies of immune cell regulation in the context of cancer therapy. This includes the identification of novel key proteins in immune regulation in different immune cell types as well as expanding insights into the mechanism of action of current and emerging immune modulating cancer drugs. Mechanisms of resistance to immune modulating cancer drugs will also be studied. The project will explore a range a different methodologies but MS-CETSA will serve as a core discovery strategy – we will provide training in state of the art MS-CETSA techniques. Ultimately the projects aims to identifying novel drug targets and mechanistic biomarkers with implications for cancer therapy.
We are looking for a highly motivated scientist with a doctoral degree and strong background in mechanistic cell biology including imaging, cell sorting, genetic and molecular biology techniques. Experiences in omics data generation and analysis is a plus as well as previous research on immune cell biology.
Applicants are expected to work independently but as part of a multidisciplinary team and to be proficient in English. They are expected to play a leading role in the design and execution of their experiments as well as the analysis and the presentation/publication of the results. Before and while being in the lab, the applicant will be encouraged to apply for competitive national and international postdoctoral fellowships and career grants and will receive support in those endeavours.
Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.
The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.
Location: Department of Oncology and Pathology, Bioclinicum, Solna, Stockholm, Sweden
Type of scholarship
The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.
The position will be financed by funds from the Swedish Cancer Society administrated by the Karolinska Institute.
An application must contain the following documents in English or Swedish:
- A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
- A complete list of publications
- A summary of current work (no more than one page)
The application is to be submitted on the Varbi recruitment system.
Want to make a difference? Join us and contribute to better health for all
|First day of employment||As soon as possible|
|Reference number||STÖD 2-4430/2020|
|Last application date||05.Nov.2020 11:59 PM CET|
Click below to apply https://ki.varbi.com/se/what:job/jobID:357663/iframeEmbedded:0/where:4