PhD position in immune protein biogenesis and engineering, Technical University of Munich, Germany Closing date: Nov 30th 2020 A PhD position is available in the laboratory for Cellular Protein Biochemistry

PhD position in immune protein biogenesis and engineering, Technical University of Munich, Germany

A PhD position is available in the laboratory for Cellular Protein Biochemistry at the Technical University of Munich, Department of Chemistry and Institute for Advanced Study. Our laboratory aims at understanding how proteins fold, assemble and are scrutinized by the cellular quality control machinery. We are particularly interested in proteins of the secretory pathway – proteins that are ultimately secreted or localized on the cell surface and allow cells to interact with their environment. We use an interdisciplinary approach from protein biochemistry and structural biology to cell biology to analyze the machinery and mechanisms that monitor cellular protein biogenesis. One major model system in our laboratory are interleukins, key signaling molecules in the immune system. CURRENT PROJECTS: One major interest of our lab is the cellular folding, assembly and quality control of IL-12 family cytokines. In recent years, we have provided insights into their biogenesis and structural setup (e.g. Müller et al, PNAS, 2019; Meier et al., Nat Commun, 2019). Using these basic insights, we also rationally engineer cytokines with enhanced or new activities. The candidate will delineate mechanisms of interleukin biogenesis and spearhead engineering approaches in our lab. She/He will have the opportunity to learn and apply a wide variety of state-of-the-art techniques from in silico approaches to mammalian cell biology and work on an exciting project of immediate biomedical relevance. YOUR PROFILE: The applicant should hold a MSc in Biochemistry or related fields. Experience in protein biochemistry, structural biology and/or protein engineering is required. Experience in mammalian cell biology and/or molecular immunology is a benefit. THE ENVIRONMENT AND THE POSITION: The Technical University of Munich (TUM) is a leading research university in Europe. We are offering excellent working conditions, state-of-the-art infrastructure and an international research environment. The salary is in accordance to the Public Sector Collective Agreement on Länder (TV-L E13/66%). The position is available from Jan 2020 on. Only applications received until Nov 30th 2020 will be considered. The application should contain a CV, (degree) certificates, a letter of motivation and at least two possible references. Please send your application (single pdf-document) by email to: matthias.feige@tum.de TUM is an equal opportunity employer. Qualified women are therefore particularly encouraged to apply. Applicants with disabilities are treated with preference given comparable qualification. further information: www.cell.ch.tum.de

Our laboratory aims at understanding how proteins fold, assemble and are scrutinized by the cellular quality control machinery. We are particularly interested in proteins of the secretory pathway – proteins that are ultimately secreted or localized on the cell surface and allow cells to interact with their environment. We use an interdisciplinary approach from protein biochemistry and structural biology to cell biology to analyze the machinery and mechanisms that monitor cellular protein biogenesis. One major model system in our laboratory are interleukins, key signaling molecules in the immune system.

CURRENT PROJECTS:
One major interest of our lab is the cellular folding, assembly and quality control of IL-12 family cytokines. In recent years, we have provided insights into their biogenesis and structural setup (e.g. Müller et al, PNAS, 2019; Meier et al., Nat Commun, 2019). Using these basic insights, we also rationally engineer cytokines with enhanced or new activities. The candidate will delineate mechanisms of interleukin biogenesis and spearhead engineering approaches in our lab. She/He will have the opportunity to learn and apply a wide variety of state-of-the-art techniques from in silico approaches to mammalian cell biology and work on an exciting project of immediate biomedical relevance.

YOUR PROFILE:
The applicant should hold a MSc in Biochemistry or related fields. Experience in protein biochemistry, structural biology and/or protein engineering is required. Experience in mammalian cell biology and/or molecular immunology is a benefit.

THE ENVIRONMENT AND THE POSITION:
The Technical University of Munich (TUM) is a leading research university in Europe. We are offering excellent working conditions, state-of-the-art infrastructure and an international research environment. The salary is in accordance to the Public Sector Collective Agreement on Länder (TV-L E13/66%). The position is available from Jan 2020 on. Only applications received until Nov 30th 2020 will be considered.

The application should contain a CV, (degree) certificates, a letter of motivation and at least two possible references. Please send your application (single pdf-document) by email to: matthias.feige@tum.de
TUM is an equal opportunity employer. Qualified women are therefore particularly encouraged to apply. Applicants with disabilities are treated with preference given comparable qualification.

further information: www.cell.ch.tum.de

Data Protection Information:
When you apply for a position with the Technical University of Munich (TUM), you are submitting personal information. With regard to personal information, please take note of the Datenschutzhinweise gemäß Art. 13 Datenschutz-Grundverordnung (DSGVO) zur Erhebung und Verarbeitung von personenbezogenen Daten im Rahmen Ihrer Bewerbung. (data protection information on collecting and processing personal data contained in your application in accordance with Art. 13 of the General Data Protection Regulation (GDPR)). By submitting your application, you confirm that you have acknowledged the above data protection information of TUM.

Kontakt: matthias.feige@tum.de

MORE INFORMATION

http://www.cell.ch.tum.de

Closing date: Nov 30th 2020
A PhD position is available in the laboratory for Cellular Protein Biochemistry

at the Technical University of Munich, Department of Chemistry and Institute for Advanced Study.

The application should contain a CV, (degree) certificates, a letter of motivation and at least two possible references. Please send your application (single pdf-document) by email to: matthias.feige@tum.de

 

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